It was as early as July 1953, when the State of Andhra was settling down with its new identity in the brave young Republic of India, that Little Flower High School was established. With all their noble ideals and aspirations, the founding fathers perhaps never thought that the institution would grow to become a landmark in the modern city of Hyderabad.

The Montfort Brothers of St. Gabriel under the able guidance of Rev. Bro. John of God set up the school with Rev. Bro. Britto as its first Principal. It was the need of the hour then, to provide sound education to a new generation of an independent nation. All Saints' High School at Gunfoundry, established in 1855 was finding it difficult to cater to the perennial demand for admissions. Thus a new school was set up just across the main street, to mark the centenary celebrations of All Saints.

The land was first leased out by the Diocese of Hyderabad for 99 years. Later the ownership was transferred to the Society of the Montfort Brothers. Classes were started in temporary sheds from Kindergarten to Class VIII with two sections each. By 1957 there were classes till X with three sections each.

It was recognised officially by the Government on the 16th of July 1960 under the Recognition No. 645/G1/60 as a minority institution. It received the ceiling grant up to September 1963. The institution followed the HSLC course and later had the multi-purpose scheme from 1963 and came back to the SSC course according to the changing trends of the educational system.